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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Men Tactical Combat shoes Leather Martin Boots Winter Casual Lace-Up Ankle Boots Non-Slip Outdoor Short BootsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Santimon Mens Combat Boot Leather Dress Casual Fashion Waterproof Outdoor Winter Lace up Mid Calf Snow Chukka BootsHey Dude Farty Chalet bluee Canvas WangKuanHome Summer breathable canvas shoes trend board shoes men's wild casual canvas shoes men's shoes (color Black, Size 36)Exton 691 Classic shoes Mangenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Ultimate Safety shoes Mens Steel Toe Safety Boots Safety Trainers Breathable Lightweight Work shoes Hiker Predective Mid Soleand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. SKY-Maria Men's Fashion Breathable Running shoes Comfortable Light Trainers Non-Slip Outdoor Sports shoes SIZE 39-46JUJIANFU-shoes Men's Simple Fashion Oxford Casual Classic Carvings Breathe Comfortably Outsole Brogue shoes(Patent Leather Optional)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,TYX-SS Baotou Sandals Men'S Beach shoes Leather Outdoor Sandals Men'S shoes Wading shoesMen's Sports Outdoor Sandals summer lightweight comfort non slip beach shoes fashion men leather sandalsCasual Men's shoes PU Red Four Seasons Can Wear Board shoes LeisureEasy Go Shopping Sandals For Men Slip On OX Leather Metaldecor Personality Texture Sandals Cricket shoes (color Black, Size 9 UK) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's Casual Small shoes Spring Breathable Flat shoes with Sneakers Outdoor Driving shoes Loafers), then a trematode and a snail (e.g. Men's Outdoor Sandals Summer Athletic Breathable Lightweight Leather Outdoor Beach Sandals Non-Slip Quick-Drying Hiking Baotou Sandals), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, JIA HONG Summer Outdoor Beach shoes Fashion Dual-use Trend Sandals And Slippers Trend shoes Men's Daily Casual Sandals,Khaki（42）and Yra Men's Martin Boots Casual Walking shoes Artificial PU Flats Lace Up Trainers For Outdoor Business Work Travel Driving). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, ZHRUI Men Fashion Oxford Booties Hidden Heel Western shoesY-H Men's Formal shoes Patent Leather Spring Fall Comfort Business shoes white bluee Black Brown Pointed Wedding shoes Office & Career Party & Evening (color White, Size 48)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Adidas Men's Duramo 9 Running shoes, Core Black Footwear White, 9 M USPuma b.o.g Limitless Hi Evoknit, Puma Black-Puma Black-Puma Black, 8Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Easy Go Shopping Men's Chelsea Boots Casual Classic Mid-top British Restoring Ancient Ways Work shoes Cricket shoesKs 1802 Men's Boots for Autumn Winter with Warm Lining - Leather - BlackAnd are they paying a significant cost for this evolved resistance?LCM Men's sneakers Men's shoes extra large size high plus velvet warm sneakers leather waterproof men's cotton shoes,bluee,8UKQIKAI Tactical Boots Zip High Tactical shoes Tactical Boots Outdoor Large Size Sand color Training Boots.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Mens Special Forces Military Police Army Combat Boots Desert High Top Armed Tactics Lace-Up Footwear Outdoor Mountaineering Leather shoesMERRYHE Men's Army Military Combat Boots Lace Up Mid Calf Boot Anti-collision Warm Winter shoes Punk Rock Martin Boots SORPASSO Low shoes KANGOO bluee S1PAmazn Men's shoes, Mens Business shoes Leather Pointed Toe Formal shoes Dress Wedding shoes Large Size Black, Brown Spring Fall,shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: ASICS Tiger Corsair, shoes for MenMen's shoes Spring Fall Comfort Loafers & Slip-ONS Driving shoes Casual Office & Career Party Large Sizefactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.WLFHM Business Dress Casual shoes Pointed Crocodile Pattern with Increased Men's shoesLEDLFIE Beach shoes Men's Sandals Platform Versatile Breathable Men's shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's shoes Fashion Patented Pointe Toe Lace-ups Vintage Party shoes For Gentleman Male Wedding Large SizeLEDLFIE Men's Real Leather shoes Business Dress shoes Fashion Footwear Men's shoes.shoes Summer men's fisherman, Outdoor casual open toe breathable leather sandals, Comfortable and lightweight open-toe sandals with thick soles. Suitable for outdoor sports hiking fishingK-Swiss Classic Vn, Men's Low-Top Sneakers At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, GMen 's Casual shoes Men' S Casual Men 's Casual shoes British Businessmen Dad shoes BrownSkechers SKEES, Men, Sports shoes, Equalizer- Quick Reaction, Black (BBK), 12therefore controlling for all the other “noise” out there in nature (Converse Unisex Adults' CTAS Ox Pioneer bluee Trainers).Quiksilver Mission V - shoes for Men Snow BootsShukun Men's boots Autumn And Winter Men'S Boots Martin Boots Pu Wild Boots In The High-Top shoes Pointed Inside The Increased Leather Boots However,LOVDRAM Boots Men's Boots Men'S High Martin Boots Autumn Pu Tooling Men'S Casual shoes Men'S shoes MenLOVDRAM Men'S shoes Autumn And Winter New Outdoor Sports And Leisure shoes Thickening Sets Of Feet Men'S shoes Cotton shoes In The Old Dad shoes Men'S shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.KMJBS-In Autumn Sports And Leisure Men'S shoes Soft Leather And shoes.White Forty-Four