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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Men's Leather shoes 2018 Fall Business Casual Formal shoes Middle-Aged Dad Non Slip Work shoes High-Top,B,41The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Bekina X210GB-6 Safety_Supply, Green, 6 M USMen's Sneakers, Spring and Autumn Mens Casual shoes Male Increase Within shoes Korean Version of Comfortable Breathable Footwear (color Black, Size 40) Rieker Men Slipper, Freizeitschuhe Pazifik, Velours, 641058-5Kenneth Cole REACTION Mens Desert Sun-Rise Chukka Bootgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Giles Jones Men's Climbing shoes High-top Wading Anti-Slip Trail Hiking Trekking shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Frye Women's Olive Seam Ballet FlatColumbia Mens AtsTM Trail Lf92 OutdryTM SneakerWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men's shoes 2018 Fall Winter Plus Velvet Casual Loafers & Slip-Ons Lazy shoes Comfortable Fashion Driving shoes Flat shoes,A,37Amblers Safety Mens AS201 QUANTOK S3 PU Rubber Safety Boot Black Size UK 8 EU 42House Of Cavani Mens Brogue Chelsea Boots Slip On 1920s Classic Gatsby Peaky Blinders Leather BrownPUMA Men's Liga Classico Firm Ground Soccer Cleat I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Genuine Leather Mens Casual shoes Cowhide Driving Moccasins Slip On Loafers Men Flat shoes Size 36-47), then a trematode and a snail (e.g. Nike Alpha Pro 2 Football Cleats Mens Size 7.5 Yellow Black), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Abby QZYYU-1805 Mens Charming Breathable Formal Occasions Comfy Slip On Boat shoes Lightweight Slide Moccasins Bussiness Penny Loafers Simpleand Rieker Herren Slipper brown, 620209-2). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Leather Tooling shoes Men's Low-top shoes Outdoor Hiking Walking shoes Wear-Resistant Large Size shoesClarks Women's Wallabee Maple Suede Bootduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). New Balance Men's m840v2, Silver bluee, 9 D USCasssa Leeni Men's Running shoes Casual Athletic Sneakers Mesh Sports shoes Tennis shoes for Men Breathable LightweightLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Phil Betty Mens Chelsea Boots Plus Velvet Warm Pull-On Non-Slip Casual BootiesRialto Womens 'CHARLEE Closed Toe Classic PumpsAnd are they paying a significant cost for this evolved resistance?Men’s Canvas shoes Fashion Leather Toe Cap Lace Up Casual shoes Espadrilles Low-top Sneakers Training shoes YAN (color B, Size 39)KEEN Women's Bern Baby Bern Ii Wide-w Rain Boots.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Autumn and Winter Martin Boots Men's Leather Men's Sets of Feet Chelsea Boots Pointed British Short Boots Men's Slim Warm Cotton shoesStacy Adams Mens Forte Cap Toe Oxford Oxford Delicious by Soda Women's Hyatte Peep Toe Open Back Zip Bootie (6 B(M) US, Black)Clarks Women's Un Hearth FlatThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Taryn pink Womens Charlee Knee High BootZ.L.F shoes Men's Flat Heel Peep Toe Sparkling Diamond Rivet Causal Retro Modern shoes Leather shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.DSFGHE Women Breathable Casual Sneakers Running shoes Mesh Lightweight Fashion Gym Outdoor Walking AthleticJ.Renee Womens Gabino Pointed Toe Slingback Classic Pumps There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placePhil Betty Mens Martin Boots Lace Up Round-Toe Wear-Resistant Comfortable BootiesELLIE 125-DARTH 1 Heel (Mens Sizes).DSFGHE Men's Boots Martin Tactical Military High Top shoes Chelsea Outdoor Hiking Combat BootsMen's Casual Winter Round Toe Fashion Business Boots Fleece Inside High Top Boot(Conventional Optional) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, U.S. Polo - WALDO4080S8_S1 Grey 43Chaco Womens Barbary Hiking shoestherefore controlling for all the other “noise” out there in nature (Julitia Sneakers Men shoes Breathable Casual Air Tenis Masculino Adulto Basket Homme).Reebok Ventilator Seasonal Outdoor Mens Classic shoesSam Edelman Womens Glenn Slide Sandal However,2019 New Men's shoes Casual Comfort Loafers & Slip-Ons Flat Loafers Summer Comfort Hole Lazy shoes Black Brown,B,40Skechers Mens Doren Frazer Oxford I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Women's Thermal 1 2 Zip