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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Xposed New Mens Real Leather Black Brogue shoes Lace up Smart Formal Office UK Size 6 7 8 9 10 11 11.5The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Mens Mid-Calf Riding Boots Waterproof Leather Buckle Martin Boots Long Military BootsNike Men's Mayfly Woven, Team Royal Off White-Black Vans Brooklyn, Men's High-Top TrainersMargaritaville Men's Escape Flip Flopgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, New Balance Numeric White-Black 440 shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. JIALUN-shoes Classic Men's Loafers Casual Boat shoes Faux Leather Slip On Driving Moccasins (Hollow Optional)Nike Men's Trainerendor Game Royal Black White White Training shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Altercore 350 Military Punk shoes Red Burgubdy Rub-Off Leather Unisex Ladies Men's 3 Eye Army Steel Toe RangerSELCNG Hiking shoes Unisex Walking shoes Waterproof Walking shoes Men's Walking shoes with Outdoor Sports Hiking shoes Non-Slip outsole-grey-42CLARKS Clarks Mens shoes Glement Slip Black LeatherLe Coq Sportif Gaspar Leather Low-153, Men's Low-Top Sneakers I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. TYX-SS Summer Sandals Casual Men'S shoes Large Size Boat shoes Casual One Pedal), then a trematode and a snail (e.g. Clarks Originals Mens Desert Peak Leather Boots in Tan- Pull On Boots-), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, KANGLE Men'S Outdoor Sports Hiking shoes Leather Breathable Casual shoes Non-Slip Waterproof Walking shoes For Trekking, Travelling,Camping, Bikingand Snfgoij Work shoes Men Safety Trainers Waterproof Lightweight Walking Martin Boots Mid-Boots Winter Boots High-top shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Arrow Men's Brunswick bowling shoes black limeNike Men's 801780 Running shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). DeWALT Maxi Safety Boots Black 7 UKAmblers Safety Safety FS161 Lace Up Boots Larger SizesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Old Friend Men's Wisconsin SlipperScott Hawaii Men's Makoa Flip-FlopAnd are they paying a significant cost for this evolved resistance?QIKAI Military Boots for Men Large Size Martin Boots High-top shoes Outdoor Leather Desert Boots Army Boots Snow BootsFuweiEncore Men's Canvas shoes Casual shoes Lofo shoes Comfortable Comfortable Lazy shoes (color 2, Size 40EU).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).WEGCJU Men's Martin Boots Chukka Wear Hiking shoes Chelsea Desert Boots Slip High Predection Waterproof Military BootsMens Big Head Leather shoes High Help Martin Boots Windproof and Warm Comfortable Non-Slip Work Boots Desert Boots Le Coq Sportif Verdon Sport Cover BlackNike 876899-402 Tanjun Premium Mens Casual shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Mustang Men's Lace-Up Flats Grey grey (Stein 200)IGI&CO grey Scuro Scarpa men Stringata Bassa 2117222factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.WLFHM Men's Summer shoes Increased in The UK Business Dress Men's shoes Increased Leather shoesLEDLFIE Men's Sandals Summer Slippers Platform Beach shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeGola Mens X-Pand Force Running TrainersLEDLFIE Men's Real Leather shoes Hollow Casual shoes Leather shoes.VALLEgreen 36842 Lace-Up Flats ManCole Haan Men's Wayne Wingtip Oxford At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Autumn And Winter Men Tooling shoes Lace Bulk shoes England Casual shoes Single shoesLambretta Mens Carnaby Fasshion Desert Boots - Gum - LG 14131therefore controlling for all the other “noise” out there in nature (Fred Perry Men's Spencer Canvas Suede Sneaker).CrazyQuick CQ Malice Rugby Boots, Yellow, 7 UKClarks Fulham Limit, Men’s Lace-Up However,golden Retriever Men's 6 Waterproof Work BootGeox Men's U Dennie B Low-Top Sneakers I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Vans Unisex Adults' Sk8-Hi Hi-Top Trainers, Black ((Mix Checker) Black True White Q9B), 10.5 UK 45 EU